Heparin sodium CAS 9041-08-1

Nkọwa dị mkpirikpi:

Aha kemịkalụ:Heparin lithium

Aha ọzọ:Heparin sodium nnu

Nọmba CAS:9041-08-1

Ọkwa:Enwere ike ịgba ọgwụ / Topical / Crude

Nkọwapụta:EP/USP/BP/CP/IP

Njirimara kemịkalụ:Heparin sodium na-acha ọcha ma ọ bụ na-acha ọcha ntụ ntụ, enweghị isi, hygroscopic, soluble na mmiri, ihe na-adịghị ike na organic mgbaze dị ka ethanol na acetone.Ọ nwere ụgwọ ọjọọ siri ike na ngwọta mmiri ma nwee ike ijikọta ya na ụfọdụ cations iji mepụta ogige molekụla.Ngwọta mmiri na-esiwanye ike na pH 7. Ọ nwere ọtụtụ ihe eji eme ihe na nkà mmụta ọgwụ.A na-eji ya na-agwọ nnukwu myocardial infarction na pathogenic ịba ọcha n'anya.Enwere ike iji ya na ribonucleic acid mee ka ọrụ ịba ọcha n'anya B dịkwuo mma. Mgbe ejikọtara ya na chemotherapy, ọ bara uru iji gbochie thrombosis.Ọ nwere ike ibelata lipids ọbara ma melite ọrụ mgbochi mmadụ.nwekwara ọrụ.

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Heparin sodium bụ ọgwụ anticoagulant, nke bụ ihe mucopolysaccharide.Ọ bụ nnu sodium nke glucosamine sulfate nke ewepụtara na mucosa intestinal nke ezi, ehi na atụrụ.etiti.Heparin sodium nwere ọrụ nke igbochi nchịkọta platelet na mbibi, na-egbochi ntụgharị nke fibrinogen n'ime fibrin monomer, na-egbochi ịmepụta thromboplastin na iguzogide thromboplastin kpụrụ, na-egbochi ntụgharị nke prothrombin n'ime thrombin na antithrombin.

Heparin sodium nwere ike igbu oge ma ọ bụ gbochie coagulation ọbara ma na vitro ma na vivo.Usoro ọrụ ya dị oke mgbagwoju anya ma na-emetụta ọtụtụ njikọ na usoro coagulation.Ọrụ ya bụ: ①Na-egbochi nhazi na ọrụ nke thromboplastin, si otú a na-egbochi prothrombin ịghọ thrombin;②N'ihe dị elu dị elu, ọ nwere ike igbochi thrombin na ihe ndị ọzọ na-akpata coagulation, na-egbochi fibrinogen ịghọ Protein fibrin;③ nwere ike igbochi mkpokọta na mbibi nke platelet.Na mgbakwunye, mmetụta anticoagulant nke sodium heparin ka na-ejikọta ya na radical sulfate na-adịghị mma na molecule ya.Ngwunye alkaline na-akwụ ụgwọ nke ọma dị ka protamine ma ọ bụ toluidine blue nwere ike wepụ ụgwọ ọjọọ ya, ya mere ọ nwere ike igbochi anticoagulant ya.coagulation.N'ihi na heparin nwere ike ịgbalite ma hapụ lipoprotein lipase n'ime ahụ, hydrolyze triglyceride na lipoprotein dị obere na chylomicrons, yabụ na ọ nwekwara mmetụta hypolipidemic.

Enwere ike iji sodium heparin na-agwọ nnukwu ọrịa thromboembolic, na-ekesa coagulation intravascular (DIC).N'ime afọ ndị na-adịbeghị anya, achọpụtara heparin nwere mmetụta nke iwepụ lipids ọbara.Ngwunye ime n'ime nwa ma ọ bụ ntụtụ intramuscular miri emi (ma ọ bụ ntụtụ subcutaneous), nkeji 5,000 ruo 10,000 oge ọ bụla.Heparin sodium dị obere na-egbu egbu na ọbara ọgbụgba n'onwe ya bụ ihe ize ndụ kachasị mkpa nke ịdoụbiga mmanya ókè heparin.N'ọnụ na-adịghị arụ ọrụ, a ga-eji ntụtụ mee ya.Intramuscular injection or subcutaneous injections na-akpasu iwe karịa, mgbe ụfọdụ mmeghachi omume nfụkasị ahụ nwere ike ime, na ịṅụbiga mmanya ókè nwere ike ime ka njide obi;ntutu isi na-adịru nwa oge na afọ ọsịsa.Tụkwasị na nke ahụ, ọ ka nwere ike ịkpata mgbaji na mberede.Iji ogologo oge eme ihe nwere ike ibute thrombosis mgbe ụfọdụ, nke nwere ike ịbụ nsonaazụ anticoagulase-III depletion.Heparin sodium bụ contraindicated na ndị ọrịa nwere ọbara ọgbụgba, oke imeju na akụrụ ezughi oke, ọbara mgbali elu, hemophilia, hemorrhage intracranial, ọnya peptic, ụmụ nwanyị dị ime na mgbe ịmụ nwa, etuto visceral, trauma na ịwa ahụ.